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Purpose: To evaluate the predictability, safety, and long term stability of transepithelial
PRK for the correction of the high and very high myopia and astigmatism using the
Profile-500 Gaussian beam excimer laser.
Methods: We choose at random 10 patients，18 eyes，with high（8 eyes）and
very high myopia（10eyes）．Among the 7 females and 3 males．Mean
age was37.7 years. Before the transepithelial PRK there was routine refractive
examinations，contrast
sensitivity and endothelial cell counts. After the operation we tried to
evaluate the operation，using by KR-9000 PW Wavefront analyzer and
TMS-2N videokeratotopograph．
Results：Mean Spherical Equivalent before the
operation was -11.5+/-0.38D，after the operation was -1.75+/-0.42D.
Three eyes were operated twice due to haze classified as Fantes 1 to 2.
Wavefront analyzer and Fourier Analysis show the appearance of prismatic
effect. There is not significant high
order irregularity. After the second operation all three eyes decrease haze level
to Fantes 0.5．
Conclusion : Ablation patterns of the Gaussian beam at a given fluence level of the
Profile-500 gives us aspherical surfaces with optimal balance between defocusing
and spherical aberration for patient with high myopia. We can not see significant
reduction of contrast sensitivity. In some case with haze for 3 to 12 months
contrast sensitivity reduced, however after disappearing of haze the contrast
sensitivity returned to the previous level.
Biochemical Investigations of Lacrima in Early
Diagnosis of Keratoconus
Author(s): Leonid
Legkikh1, M. Koledintsev2, A. Semenova2,
K.Okuyama3
Hospital
or Institution: 1. Svyatoslav Fyodorov S.I. Eye Microsurgery complex, Beskudnikovsky
Blvd.59A 127486, Moscow, Russia Moscow, Russia
2.
Moscow Medical Stomatological University, Moscow, Russia
3.Sangubashi
Eye Clinic, Tokyo, Japan
Purpose: To study results of biochemical investigation of lacrimal fluid in
patients with initial keratoconus to develop tests of early diagnosis of
disease.
Methods: 26 patients with initial keratoconus aged from 16 to 44 years were
examined The control group consists of 20 practically healthy
people in the same age. The biochemical investigation of
lacrima was performed with the biochemical analyzer.
Results : The biochemical analysis of lacrima showed, that an
increase of activation of Lactate dehydrogenase, creatine
phosphokinase, amylase etc. These data in combination with an increase of
general protein and products of albuminolysis(urea, uric
acid) compared with the control group is notable
for patients with initial keratoconus.
Conclusion: The method of biochemical analysis of lacrimal fluid
can be used in the early diagnosis of keratoconus.
Immunologic Investigations of Lacrima in early
Diagnosis Keratoconus
Author(s): Anna Semenova 1, M. Koledintsev 2, L. Legkikh 1,
K. Okuyama 3
Hospital or
Institution: Svyatoslav Fyodorov S.I."Eye Microsurgery Complex
Address for
Correspondence: Beskudnikovsky Blvd. 59A, 127486, Moscow, Russia
E-mail :semenaru @yahoo.com
Tel: (095)
488-8424 Fax: (095) 905-5333
Purpose: To study results of immunologic investigations of lacrima in patients
with initialkeratoconus for development of tests of early diagnosis of
disease
Setting/Venue：1．Svyatoslav
Fyodorov S.I. Eye Microsurgery Complex，Moscow，Russia
2．Moscow
Medical Stomatological University．
3．Sangubashi
Eye Clinic，Tokyo，Japan．
Methods: 26 patients with initial keratoconus aged from 16 to 44 years were examined.
The Control group consists of 20 practically healthy people of the same age. The
immunologic investigation of lacrima included a determination of concentration of
A，M，G immunoglobulins by method of Manchini G．Radial
immunodiffusion．
Results: The immunologic investigation of lacrima showed a significant Ig A increase
in18 of 26 patients(69.2%). A significant increase Ig G in 53.8%.
We noted a tendency
to increase of Ig M compared with the control. The difference was not
significant. Thus, considerable differences in the level of immune proteins of lacrima
were noted in patients with keratoconus compared with the control..
Conclusions: Methods of immunologic investigation of lacrima can
be used in the early diagnosis of keratoconus．
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