Wave-front and Fourier Analysis of the High Myopia Transepithelial PRK on Profile-500
Author（s）：Kodo Okuyama，Viktor Movshev
Hospital or Institution：Sangubashi Eye Clinic，IRTC Microsurgery
Address for Correspondence: 1-2-15-201 Higashigotanda Shinagawa-ku Tokyo JAPAN
Tel : 81+3+34463902Fax : 81＋3＋3782178
Email：okuyama＠k.email.ne.jp
Purpose: To evaluate the predictability, safety, and long term stability of transepithelial PRK for the correction of the high and very high myopia and astigmatism using the Profile-500 Gaussian beam excimer laser.
Methods: We choose at random 10 patients，18 eyes，with high（8 eyes）and very high myopia（10eyes）．Among the 7 females and 3 males．Mean age was37.7 years. Before the transepithelial PRK there was routine refractive examinations，contrast sensitivity and endothelial cell counts. After the operation we tried to evaluate the operation，using by KR-9000 PW Wavefront analyzer and TMS-2N videokeratotopograph．
Results：Mean Spherical Equivalent before the operation was -11.5+/-0.38D，after the operation was -1.75+/-0.42D. Three eyes were operated twice due to haze classified as Fantes 1 to 2. Wavefront analyzer and Fourier Analysis show the appearance of prismatic effect. There is not significant high order irregularity. After the second operation all three eyes decrease haze level to Fantes 0.5．
Conclusion : Ablation patterns of the Gaussian beam at a given fluence level of the Profile-500 gives us aspherical surfaces with optimal balance between defocusing and spherical aberration for patient with high myopia. We can not see significant reduction of contrast sensitivity. In some case with haze for 3 to 12 months contrast sensitivity reduced, however after disappearing of haze the contrast sensitivity returned to the previous level.
Biochemical Investigations of Lacrima in Early Diagnosis of Keratoconus
Author(s): Leonid Legkikh1, M. Koledintsev2, A. Semenova2, K.Okuyama3
Hospital or Institution: 1. Svyatoslav Fyodorov S.I. Eye Microsurgery complex, Beskudnikovsky Blvd.59A 127486, Moscow, Russia Moscow, Russia
2. Moscow Medical Stomatological University, Moscow, Russia
3.Sangubashi Eye Clinic, Tokyo, Japan
Purpose: To study results of biochemical investigation of lacrimal fluid in patients with initial keratoconus to develop tests of early diagnosis of disease.
Methods: 26 patients with initial keratoconus aged from 16 to 44 years were examined The control group consists of 20 practically healthy people in the same age. The biochemical investigation of lacrima was performed with the biochemical analyzer.
Results : The biochemical analysis of lacrima showed, that an increase of activation of Lactate dehydrogenase, creatine phosphokinase, amylase etc. These data in combination with an increase of general protein and products of albuminolysis(urea, uric acid) compared with the control group is notable for patients with initial keratoconus.
Conclusion: The method of biochemical analysis of lacrimal fluid can be used in the early diagnosis of keratoconus.
Immunologic Investigations of Lacrima in early Diagnosis Keratoconus
Author(s): Anna Semenova 1, M. Koledintsev 2, L. Legkikh 1, K. Okuyama 3
Hospital or Institution: Svyatoslav Fyodorov S.I.”Eye Microsurgery Complex
Address for Correspondence: Beskudnikovsky Blvd. 59A, 127486, Moscow, Russia
E-mail :semenaru @yahoo.com
Tel: (095) 488-8424 Fax: (095) 905-5333
Purpose: To study results of immunologic investigations of lacrima in patients with initialkeratoconus for development of tests of early diagnosis of disease
Setting/Venue：1．Svyatoslav Fyodorov S.I. Eye Microsurgery Complex，Moscow，Russia
2．Moscow Medical Stomatological University．
3．Sangubashi Eye Clinic，Tokyo，Japan．
Methods: 26 patients with initial keratoconus aged from 16 to 44 years were examined. The Control group consists of 20 practically healthy people of the same age. The immunologic investigation of lacrima included a determination of concentration of A，M，G immunoglobulins by method of Manchini G．Radial immunodiffusion．
Results: The immunologic investigation of lacrima showed a significant Ig A increase in18 of 26 patients(69.2%). A significant increase Ig G in 53.8%.
We noted a tendency to increase of Ig M compared with the control. The difference was not significant. Thus, considerable differences in the level of immune proteins of lacrima were noted in patients with keratoconus compared with the control..
Conclusions: Methods of immunologic investigation of lacrima can be used in the early diagnosis of keratoconus．
